Modecate injection dosage


  1. Modecate Injection 25mg/ml 2 QUALITATIVE AND QUANTITATIVE COMPOSITION Each ampoule contains 25mg/ml of the active substance Fluphenazine Decanoate
  2. Fluphenazine Decanoate for Injection: -Initial dose: 12.5 to 25 mg deep IM injection into the gluteal region. -Maintenance dose: 12.5 to 100 mg IM, usually every 3 to 4 weeks. -Maximum dose: 100 mg/injection. Fluphenazine HCl for Injection: -Initial dose: 2.5 to 10 mg IM, given as divided doses every 6 to 8 hours. -Maximum dose: Up to 10 mg/day
  3. The initial dose is 16.25-25 mg intramuscularly or subcutaneously every two weeks until a steady-state effect is achieved. At this point, a single injection can last for 4-6 weeks. If the patient needs a higher dose, then the dose can be repeated or increased cautiously every one to three weeks, in increments of 12.5 mg

Dosage & Administration Fluphenazine Decanoate by deep intramuscular injection into the gluteal muscle, test dose 12.5 mg (6.25 mg in elderly), then after 4-7 days 12.5-100 mg repeated at intervals of 14-35 days, adjusted according to response; it is not recommended for children injection Administer missed dose ASAP. ≥24 weeks since last injection •Stabilize on POantipsychotic • Re-initiate fluphenazine decanoate Drug FDA-Approved Indications Dosing Earliest Time to Next Dose Missed Dose VIVITROL® (naltrexone)11 • Dosage Forms opioid 380 mg vial and syringe kit •Alcohol dependence Prevention of dependenc Before using Modecate Injection, inform your doctor about your current list of medications, over the counter products (e.g. vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions (e.g. pregnancy, upcoming surgery, etc.).Some health conditions may make you more susceptible to the side-effects of the drug For most patients, a dose of 12.5 to 25 mg (0.5 to 1 mL) may be given to initiate therapy. The onset of action generally appears between 24 and 72 hours after injection and the effects of the drug on psychotic symptoms becomes significant within 48 to 96 hours Discontinuation of Fluphenazine Decanoate (Modecate) Depot Sanofi have announced the discontinuation of fluphenazine injection by mid 2018 due to commercial reasons. Availability of the depot is expected to continue until the end of 2018. The decision to discontinue fluphenazine should be made by a specialist and patients in primary car

This drug is not approved for treatment of patients with dementia-related psychosis. This medication contains fluphenazine. Do not take Modecate, Modecate Concentrate, Moditen, Prolixin, or RhoFluphenazine if you are allergic to fluphenazine or any ingredients contained in this drug. Keep out of reach of children

Fluphenazine Dosage Guide + Max Dose, Adjustments - Drugs

The usual starting dose is 1.25 mg IM. Depending on the severity and duration of symptoms, the total initial daily dosage may range from 2.5 mg/day to 10 mg/day and should be divided and given at 6 to 8 hour intervals. Doses exceeding 10 mg/day should be used cautiously Initially: 12.5-25mg IM or SC every 4-6 wks; max 100mg/dose Each mL of injectable solution contains 100 mg of fluphenazine decanoate. Nonmedicinal ingredients: benzyl alcohol 1.5% w/v (preservative) and sesame oil. How should I use this medication? This medication is given as an intramuscular (into the muscle) injection at your doctor's office or clinic on a regular basis (usually every 2 to 3 weeks)

Fluphenazine (Modecate): MOA, Uses, Dosage, Side Effect

1. What Modecate is and what it is used for. The name of your medicine is Modecate 25mg/ml Injection (called Modecate throughout this leaflet). Modecate contains a medicine called fluphenazine decanoate. This belongs to a group of medicines called 'phenothiazines'. It works by blocking the effect of a chemical in the brain Depending on the severity and duration of symptoms, initial total daily dosage may range from 2.5 to 10 mg and should be divided and given at six to eight hour intervals Fluphenazine Decanoate Injection, USP, 25 mg/mL is available in 5 mL multiple dose vials, packaged in individual cartons. NDC 0143-9529-01 (and dosage form): MODECATE INJECTION COMPOSITION 25 mg Fluphenazine Decanoate per mL in sesame oil preserved with 1,5 % m/v benzyl alcohol. PHARMACOLOGICAL CLASSIFICATION Category A 2.6.1 Phenothiazine and derivative. PHARMACOLOGICAL ACTION Fluphenazine decanoate is an esterified trifluoromelhyl phenothiazine derivative Dosage is based on your medical condition, past use of other drugs for your condition, and response to therapy. The dose should not be greater than 100 milligrams. Inform your doctor if your..

Modecate Injection 25 mg/ml Bristol Myers Squibb

Fluphenazine long-acting injection will be given to you by a doctor or nurse. If you haven't received an injection like fluphenazine before, a small dose is usually given as a test 4-7 days before you have a full dose. This is to see how well you tolerate the injection. The injection is given into a muscle in your bottom (buttocks) Fluphenazine Decanoate Injection is a long­acting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy (e.g., chronic schizophrenics). Fluphenazine Decanoate Injection has not been shown effective in the management of behavioral com PROLIXIN® Injection (Fluphenazine Hydrochloride Injection USP) is useful when psychotic patients are unable or unwilling to take oral therapy. HOW SUPPLIED PROLIXIN® Tablets (Fluphenazine Hydrochloride Tablets USP) 5 mg: each film-coated tablet is green, round, biconvex, debossed with PPP over 877. bottles of 100 NDC 0003-0877-5

Medicine information - Kaiser Permanente

Long-Acting Injectable (LAI) Dosing Char

Modecate Concentrate 100 mg/ml Injection is a pale yellow clear liquid supplied in 0.5ml and 1ml colourless glass ampoules with an OPC (one point cut) breaking system. Not all pack sizes may be marketed Intramuscular or Subcutaneous dosage (fluphenazine decanoate in oil long-acting injection) Adults The usual initial dose 12.5 mg to 25 mg IM or subcutaneously; subsequent doses and frequency are determined by the patient's response and tolerability Hello, my partner gets modecate injections once a month for schizophrenia. usually his mother (who is a nurse) injects it to his lower back/buttocks area, but this time he injected it himself to his thigh-muscle (under his moms supervision). can this affect his reaction to the medication

The manufacturer of fluphenazine decanoate (Modecate ®) injection has written to healthcare professionals advising that this product will be discontinued by the end of 2018.. The letter details unpredictable supplies of the active ingredient from the single global manufacturer as the reason for this decision. It is noted that this decision is not due to any safety concerns How to use Fluphenazine Hcl Vial. Consult your pharmacist or physician. Consult your pharmacist or physician. Call your doctor for medical advice about side effects. You may report side effects to. uses. This medication is a long-acting form of fluphenazine that is used to treat certain mental/mood problems (chronic schizophrenia). Fluphenazine decanoate is usually used in patients who have benefited from regular doses of short-acting forms of fluphenazine and who may benefit from long-term (maintenance) treatment with less frequent dosing The maximum dosage is 40 mg. per day. The injection comes as 2.5 mg. per mL. Usually, 2.5 mg.-10 mg. per day is prescribed. This should be divided and given at six to eight hour intervals. • Fluphenazine decanoate. The injection dose is usually 12.5 to 25 mg. per dose, which should be increased or repeated every one to three weeks as needed

If you miss a dose of fluphenazine, take it as soon as you remember, unless it is closer to the time of your next dose. Discuss this with your healthcare provider. Do not double your next dose or take more than what is prescribed. If you miss a dose of fluphenazine long-acting injection, see your healthcare provider to receive your dose as soon. Most patients will be well maintained on a Prolixin Dec dose of 6.25 to 25 mg IM every two weeks (covering the dose range of 5 to 20 mg oral fluphenazine daily); only a minority of patients should need high-dose regimens of 37.5 or 50 mg IM every two weeks. Typical dose: 6.25-25 mg every 2-4 weeks. General conversion formula: For each 10 mg/day. Fluphenazine HCl 2.5 mg / mL Intramuscular Injection Multiple Dose Vial 10 mL APP Pharmaceuticals 63323028110 APP Pharmaceuticals 63323028110 - McKesson Medical-Surgical McKesso

Modecate Injection - Product - tabletwise

Fluphenazine decanoate is the decanoate ester of a trifluoromethyl phenothiazine derivative. It is a highly potent behavior modifier with a markedly extended duration of effect and has the following structural formula: Fluphenazine Decanoate Injection, USP is available as a clear, pale yellow solution for intramuscular (IM) or subcutaneous (SC. Review pharmacology about FLUPHENAZIINE (PROLIXIN): Side effects, uses, dosage injection), warnings, benefits, precautions, mechanism of action (moa), com.. APO-Fluphenazine [DSC]; FluPHENAZine Omega; Modecate Concentrate [DSC]; PMS-Fluphenazine; PMS-Fluphenazine Decanoate Warning There is a higher chance of death in older adults who take this drug for mental problems caused by dementia. Most of the deaths were linked to heart disease or infection. This drug is not approved to treat mental problems.

Adult: For the maintenance treatment in patient with chronic cases, requiring prolonged parenteral treatment: As fluphenazine decanoate: Usual initial dose: 12.5-25 mg via IM or SC inj, subsequent doses and dosage interval are determined based on patient response.Usual maintenance dose: 12.5-100 mg at intervals of 2 weeks to 5 or 6 weeks. If doses >50 mg are necessary, increase dose cautiously. Modecate Injection Drug Information. Are you paying too much for Modecate Injection? Save up to 80% when purchasing your prescription drugs from Universal Drugstore. Our prescription service aspires to conveniently provide you with affordable medications at the lowest prices in Canada and internationally Fluphenazine, brand name Prolixin, is an example of such a medication that has about a 15-year history of unlabeled use in horses, yet very little is written about it in horses. Fluphenazine is a member of the large group of drugs known as neuroleptics, which have their principal effect on brain function In general, the parenteral dose for fluphenazine has been found to be approximately 1/3 to 1/2 the oral dose. Treatment may be instituted with a low initial dosage, which may be increased, if necessary, until the desired clinical effects are achieved. Dosages exceeding 10 mg daily should be used with caution

Fluphenazine Injection - FDA prescribing information, side

  1. Find 6 user ratings and reviews for Fluphenazine Decanoate Injection on WebMD including side effects and drug interactions, medication effectiveness, ease of use and satisfactio
  2. istration & dosage* Humans Injections
  3. istered once every 4 weeks, at a dose based on mg equivalence between fluphenazine decanoate and haloperidol decanoate; as regards the latter, this dose was estimated.
  4. Fluphenazine Decanoate: Single-Dose Pharmacokinetics Ereshefsky L, Saklad SR, Jann MW. J Clin Psychiatry 1984;45(suppl):50-8. Paliperidone palmitate1 Haloperidol decanoate3 normalized to a 2.5-micromol/kg dose Fluphenazine decanoate4 Risperidone long-acting injection2 25-mg dose 25-mg dos

Fluphenazine and SGAs drug interaction. This case study reported the interaction of fluphenazine with SGAs. A 17-year-old African female suffering from depression with psychotic symptoms, was treated with fluphenazine decanoate 25 mg injection, diazepam 10 mg injection once, and olanzapine 10 mg/day PO daily. She presented to the hospital. Fluphenazine Decanoate by deep intramuscular injection into the gluteal muscle, test dose 12.5 mg (6.25 mg in elderly), then after 4-7 days 12.5-100 mg repeated at intervals of 14-35 days, adjusted according to response; it is not recommended for children The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is. Fluphenazine Patients who are naïve to fluphenazine should establish tolerability with oral fluphenazine prior to receipt of the LAIA formulation. No duration specified. Switching from another LAIA to paliperidone LAI: Administer paliperidone LAI in place of the next scheduled injection FLUPHENAZINE (floo FEN a zeen) is used to treat the symptoms of schizophrenia and other mental disorders. Not all fluphenazine injections are the same. Do not change the brand you are using without checking with your doctor or health care professional. Open All Questions

Modecate Injection (Fluphenazine Decanote) Prescription Settings Edit. Brand Name Choices. Modecate 25mg/mL Injection . Fluphenazine Decanote Please provide a list of all your medications and dosages. Submit . Trustpilot. Toll Free Phone: 1-866-500-6633 International Phone: +44 1438500111 Toll Free Fax: 1-866-335-927 Fluphenazine hydrochloride injection, Fresenius Kabi, 2.5 mg/mL, 10 mL vial, 1 count, NDC 63323-0281-10 DrugCentral is online drug information resource created and maintained by Division of Translational Informatics at University of New Mexico. fluphenazine decanoate DrugCentral 2021 Online drug Compendiu COMMON side effects If experienced, these tend to have a Severe expression i . tardive dyskinesia, a disorder characterized by involuntary movements of the face, mouth and tongu

  1. Older people with dementia and psychosis have a higher risk of death if they take antipsychotic medicines like Prolixin (fluphenazine). They shouldn't be given this medicine. This is a black box warning. The FDA requires this warning when there is a significant risk of serious or life-threatening effects that anyone taking the drug should consider
  2. Fluphenazine (Prolixin) received an overall rating of 6 out of 10 stars from 7 reviews. See what others have said about Fluphenazine (Prolixin), including the effectiveness, ease of use and side effects
  3. Fluphenazine Decanoate Injection is a long-acting parenteral antipsychotic drug intended for use in the management of patients requiring prolonged parenteral neuroleptic therapy (e.g., chronic schizophrenics). Fluphenazine Decanoate Injection has not been shown effective in the management of behavioral complications in patients with mental.
  4. ergic antagonist. It is a member of phenothiazines, a decanoate ester, an organofluorine compound and a N-alkylpiperazine
  5. e, imipra
  6. Fluphenazine enanthate and decanoate are given IM or SC. Oral. Give sustained release tablets whole (need to be swallowed whole; not recommended for children). Dilute oral concentrate in fruit juice, water, carbonated beverage, milk, soup. Avoid caffeine-containing beverages (cola, coffee) as a diluent, also tannic acid (tea) or pectinates.
NDC 0143-9529 Fluphenazine Decanoate Fluphenazine Decanoate

Prolixin (fluphenazine) is an antipsychotic medication used to manage schizophrenia. Common side effects of Prolixin include abnormal muscle contractions, difficulty breathing and swallowing, neck spasms, low blood pressure, constipation, dry mouth, blurred vision, seizures, dizziness, and drowsiness. Do not take Prolixin if pregnant or breastfeeding Fluphenazine Hydrochloride Tablets. (fluphenazine hydrochloride) Drug Summary. FDA Drug Safety Communication. Showing Results 1-5 of 5. Advertisement Phenylephrine is a medication primarily used as a decongestant, to dilate the pupil, to increase blood pressure, and to relieve hemorrhoids. When taken orally as a decongestant, it relieves nasal congestion due to colds and hay fever. It can be taken by mouth, as a nasal spray, given by injection into a vein or muscle, or applied to the skin

Prolixin Decanoate Dosage Guide - Drugs

Fluphenazine HCl Injectable Solution 2.5 mg/mL Uses. For psychosis. Instructions. This medicine is given as an injection into a muscle. Always inspect the medicine before using. The liquid should be clear or light yellow. Do not use the medicine if it contains any particles or if it has changed color. Check the medicine before each use Progesterone, per 50 mg, injection Fluphenazine decanoate, up to 25 mg, injection (Prolixin) Procainamide HCl, up to 1 g, injection (Pronestyl) Oxacillin sodium, up to 250 mg, injection (Bactocile, Prostaphlin) Neostigmine methylsulfate, up to 0.5 mg, injection (Prostigmin) Protamine sulfate, per 10 mg, injection Fluphenazine injection stays in your body longer than the oral form, and the injections are not given daily. Follow your doctor's dosing instructions very carefully. You may need frequent medical tests. Your next dose may be delayed based on the results. If you need surgery, tell the surgeon ahead of time that you are using fluphenazine Fluphenazine Prolixin® ROUTE USUAL DOSE (Range) FREQUENCY (Range) CONVERSION RATIO PO to IM OTHER INFORMATION KINETICS Oral 1mg 2.5mg 5mg 10mg 5mg/ml soln PO 2.5-20 mg/dy (2-60 mg/dy) QD - QID NA ↑ dose by 2.5mg/dy Q week. After symptoms controlled, slowly ↓ dose to 1-5mg/dy (dosed QD

Fluphenazine decanoate is usually used in patients who have benefited from regular doses of short-acting forms of fluphenazine and who may benefit from long-term (maintenance) treatment with less frequent dosing. Fluphenazine belongs to a class of medications called phenothiazines and is also referred to as a neuroleptic A multi-dose vial is a vial of liquid medication intended for parenteral administration (injection or infusion) that contains more than one dose of medication. Multi-dose vials are labeled as such by the manufacturer and typically contain an antimicrobial preservative to help prevent the growth of bacteria

Fluphenazine decanoate 25mg/1ml and 100mg/1ml solutions for injection ampoules (Modecate and Modecate Concentrate) manufactured by Sanofi, have been discontinued for some time and stock of any remaining batches will now have expired. Prescribers should complete arrangements to transfer patients on Modecate to therapeutic alternatives under medical supervision Recommended available dose formulations include 25mg/ml strength, in 5ml multiple does vials. Dose reduction may be necessary for CYP450 interactions of side effect intolerance. References: 1. APP Pharmaceuticals. (2010). Fluphenazine decanoate, injection usp. 2. American Psychiatric Association. (2020) Side effect rates for Prolixin Decanoate (fluphenazine decanoate) Manufacturers don't say how common these side effects are when taking fluphenazine decanoate for psychosis. Difficulty controlling movements. Muscle spasms. Inability to sit still. Uncontrolled eye movements. Prolonged muscle spasms

Fluphenazine Dosage & How to Take This is the usual dosage recommended in most common treatment cases. Please remember that every patient and their case is different, so the dosage can be different based on the disease, route of administration, patient's age and medical history plasma concentration occurs within the first 24-hours after intramuscular injection of fluphenazine decanoate. The onset of action is generally between 24 and 72 hours after injection of fluphenazine decanoate, and the effects of drug on psychotic symptoms become significant within 48 to 96 hours

Fluphenazine (Modecate): Schizophrenia Drug Side Effects

Fluphenazine Hydrochloride Oral Solution USP, a colorless, unflavored concentrated liquid is available in the following oral dosage form: NDC 0121-0653-04 - 120 mL bottle with a 1 mL safety-cap dropper calibrated at 0.1 mL and in 0.2 mL increments. 5 mg Fluphenazine hydrochloride per mL Appropriate dosage of Fluphenazine Appropriate dosage of Fluphenazine Decanoate Injection should be individualized for each patient and responses carefully monitored. No precise formula can be given to convert to use of Fluphenazine Decanoate Injection; however, a controlled multicentered study,* in patients receiving oral doses from 5 to 60 mg. Continue to take fluphenazine even if you feel well. Do not stop taking fluphenazine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will want to decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt Fluphenazine decanoate is a first generation antipsychotic. It is also known by the trade name Modecate. The manufacturer discontinued the drug due to a shortage of ingredients, but it is still licensed for use. You can find detailed information about this drug in the official Patient Information Leaflet (PIL)

Fluphenazine Hydrochloride Injection (fluphenazine

Modecate and Modecate concentrate injections both contain the active ingredient fluphenazine decanoate, which is a type of medicine called a phenothiazine antipsychotic. (NB. Fluphenazine is also. Fluphenazine Oil for injection 25mg Drug Medication Dosage information. Learn about the reported side effects, related class drugs, and how these medications will affect your daily lifestyle. Visit cvs.com for more details

What we do. We support people with mental illness, innovate solutions to bring back to communities, and drive change for better mental health. Learn More Drug Name Active Ingredients Strength Dosage Form/Route Marketing Status RLD TE Code Application No. Company; FLUPHENAZINE DECANOATE: FLUPHENAZINE DECANOATE: 25MG/ML: INJECTABLE;INJECTION: Prescription: No: AO: 20773 Fluphenazine : Therapeutic uses, Dosage & Side Effects Fluphenazine is a first-generation typical antipsychotic drug, used in the treatment of chronic psychoses such as schizophrenia. Dose : 1-10 mg (Oral) Route : Oral, I.M., depot injection (fluphenazine decanoate) Plasma Half-life : IM 15 hours (HCL), 7-10 days (decanoate) Duration of action : N/A Bioavailability : 2.7% (Oral) [

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The fluphenazine conversion is 1.2 times the oral dose, making the mathematics somewhat more complicated (Fluphenazine [package insert]. Richmond Hills, ONT: Novex Pharma; 2001). Atypical. FLUPHENAZINE DECANOATE. QTY 5 • 25 MG/ML • VIAL • Near 77381. Add to Medicine Chest. Set Price Alert. More Ways to Save. FLUPHENAZINE (floo FEN a zeen) is used to treat the symptoms of schizophrenia and other mental disorders. Not all fluphenazine injections are the same Seventeen outpatients were treated with depot neuroleptics, zuclopenthixol decanoate in Viscoleo or fluphenazine decanoate in sesame oil, with dosage intervals of 3 weeks. During the 4th, 6th, and 8th dosage interval blood samples were drawn in oxalated tubes. Plasma concentrations of the active neuroleptic drugs, zuclopenthixol and fluphenazine, were determined by high performance liquid.

Fluphenazine Hydrochloride Injection - FDA prescribing

The Related Drug Information Index provides comprehensive access to all drug information related to a specific drug Types of content include full prescribing information, drug summaries, Full Prescribing Information Continuing Medication Education (Full PI CME), Medication Guides, Risk Evaluation and Mitigation Strategies (REMS Summaries), REMS Continuing Medication Education (REMS CME), and. Fluphenazine injection stays in your body longer than the oral form, and the injections are not given daily. Follow your doctor's dosing instructions very carefully. You may need frequent medical. Buy Modecate Injection with a No Risk Guarantee. You can trust Affordable Drugs to provide you with affordable quality medications like Modecate Injection at the lowest possible prices. We pride ourselves on providing excellent customer service that sets us far apart from the competition Fluphenazine is a phenothiazine neuroleptic drug. In a double-blind comparison of a group of stabilized outpatients taking a low dosage of fluphenazine enanthate (1.25-5 mg every 2 weeks) with a group taking a standard dosage (12.5-50 mg every 2 weeks), relapse rates were higher in the low-dose group (56%) than in the standard-dose group (7. DOSAGE AND ADMINISTRATION. Fluphenazine Decanoate Injection may be given IM or SC. A dry syringe and needle of at least 21 gauge should be used. Use of a wet needle or syringe may cause the solution to become cloudy. To begin therapy with Fluphenazine Decanoate Injection, the following regimens are suggested

Video: Fluphenazine Decanoate Inj Dosage & Rx Info Uses, Side

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In the fluphenazine sub-group there was a second peak on day 7 and a steeper decline, so that the mean area-under-curve in week 4 was 64% of that in week 1. Drug injections at steady state induced an increase in prolactin secretion in all of the fluphenazine sub-group and in half of those receiving haloperidol 10-15 X daily PO dose = IM equivalent decanoate dose (Round to nearest 50mg). Administer Q4wks. Continue ½ PO daily dose X 1st few months. ↓ PO dose over 3 months. Accelerate taper if side effects occur. Method 2: Admin equivalent decanoate dose Q4wks. Continue PO X 1 month (or discontinue within 7 days of 2nd injection) FLUPHENAZINE (floo FEN a zeen) is used to treat the symptoms of schizophrenia and other mental disorders. Not all fluphenazine injections are the same. Do not change the brand you are using without checking with your doctor or health care professional. This medicine may be used for other purposes; ask your health care provider or pharmacist if. Fluphenazine Hydrochloride Injection, USP is a sterile, nonpyrogenic solution of fluphenazine hydrochloride in Water for Injection, for intramuscular use for the management of schizophrenia. Fluphenazine hydrochlo- ride is a trifluoromethyl phenothiazine derivative and the chemical name is 1-Piperazineethanol, 4-[3-[2